posted 04-18-2002 10:00 PM       

Here is the link to the gov patents site: http://www.uspto.gov/patft/index.html

Do a search on pinitol and a search on d-chiro inositol in the patents granted and patent applications. (100's of pages of info).

When I have a few minutes, I will post direct links to my "fave" patents. Might not be until the weekend.

Thanks for reading!

posted 04-19-2002 05:27 PM       

The above is a link to my favorite patent!! (Yes, I have a favorite patent). I urge you to print it out if you can a read it over and over. I was going to cut and paste some of my favorite information out for your research ease, but really it's best if you dig a little. It has information on human subjects using pretty darn small pinitol doses and exhibiting reductions in insulin release. No it's not proof--it's information. Take what interests you and leave the rest. I constantly read this stuff to keep me focused on the demanding lifestyle changes I have chosen--it gives me a sense of hope and a feeling of control that there is progress being made with PCOS and that I will be poised to take advantage of every beneficial development that I can.

I am choosing carob syrup right now as my pinitol source because it's easy to consume. I had success with buckwheat farinetta, too. And before that, I had success with soy lecithin and now nobody even knows why that worked!!

I have thought a lot about dosing--you know what "dose" I'm supposed to take. And how in the heck am I supposed to find out definitively what substances have exactly how much d-chiro inositol or pinitol in them? One of the researchers involved in the development of the drug now in FDA trials (INS-1) said the dosage used in the studies could be obtained from eating 27 oranges, with the peels!! A cyster could infer that it would be impossible to get d-chiro inositol from food and not pursue that avenue. But just think, he wasn't obligated to announce where else you could find d-chiro inositol and he isn't required to explain dosages. Maybe you don't required 1200mg of d-chiro inositol to benefit. Maybe you would see beneficial changes with 100mg, or 10 mg, or 3000mg. Maybe you could consume pinitol containing foods and your body converts enough to d-chiro inositol. Maybe you don't need carob syrup--Maybe 10 garbanzo beans per day would do. Maybe a can of garbanzos each day. Maybe nothing will work for you. Maybe you can bypass the problem altogether by never consuming another carb again and lowering your need for insulin. Do you see where I'm going with this ramble--nobody can tell you what will work for you and how to proceed--even when the drug comes out and you have your prescription in hand. You will still be the ultimate judge of how it works for you.

All that is out there is information and the personal laboratory named "YOU."

jgv

PS. The New England Journal of Medicine Article from (April 1999) is THE study that cracked the nut. If you can't get it, I will e mail it to you as an 99kb attachment to read in Adobe Acrobat.

Title: Ovulatory and Metabolic Effects of d-Chiro-Inositol in the Polycystic Ovary Syndrome
Volume: 340
Issue: 17
Page: 1314

posted 04-25-2002 04:56 PM      

I found the article very interesting. According to the article I am eating too much carob!
If Proactive Woman is correct there is 10% pinitol in carob powder. So in order to give me 1g of pinitol each day I would need at least 10 grammes of carob which is about half of what I am currently taking. Like jgv says, who knows how much each person needs? You just have to see what works best
Anyway, I'm going to reduce the dosage for a while and see if there's a difference.

Thanks

posted 05-02-2002 11:38 AM       

It's interesting that a supplement that used to be on the shelves at GNC for a reasonable price is now not available.

A letter that I wrote to Ed Burke, a noted expert on sports fitness and muscle issues) is below. He wrote a pamphlet style book on d-pinitol and it was never published. He probably sold to Humanetics. His answers are interspersed in my original letter to him.

jgv

on 2/2/02 11:29 PM, .com wrote:

Hello Dr. Burke,

You may or may not know that a lack of d-pinitol and d-chiro inositol is a signature issue for women with polycystic ovarian syndrome. Without boring you with the details, polycystic ovarian syndrome (PCOS) has been identified since the early 1900's as a disease/syndrome with mostly infertility and cosmetic implications. It is now thought to be a defect in insulin processing similar to Syndrome X in men and insulin resistance with a concurrent ovarian defect that leads to more serious diseases.

I been researching the issues as well as I can without the training necessary to really know what I'm doing and have been successfully treating myself by consuming soy lecithin and a buckwheat product as sources of d-pinitol or d-chiro inositol. I have success but really don't have data to help me measure and record how much of the therapeutic substance I'm consuming.

I'm writing to try to obtain a copy of your title D-Pinitol : What You Need to Know. I note that it is unavailable through conventional sources. Would you be able to get me a copy? If not, is there a resource with which I could do rudimentary research on the matter?

This book was never published. Sorry. Try this web site www.humaneticscorp.com The company Humanetics is located in Mineapolis, MN, their phone number is 612-513-9246

Also, I've read your Optimum Muscle Recovery and wonder how the information contained there would apply to someone with insulin resistance. I have had decrease in symptoms and increase in lean muscle by lowering my carbohydrate intake.

I have had many diabetics take to me that they feel better when following the 4 to 1 ratio for sports drinks. There are two products on the market that follow the principles in the book. Accelerade a drink to use during exercise and EnduroxR4 to a drink to be used in recovery.

Good luck on your research and look for the above products at www.enduroxr4.com

I appreciate any way that you can help me.

Sincerely,

----- Original Message -----
From:
To:
Sent: Sunday, February 11, 2001 8:37 AM
Subject: d pinitol, IP-6 from natural pco list

Message: 11
Date: Sat, 10 Feb 2001 18:52:02 -0000
From:
Subject: Soy Lecithin, d-Pinitol, IP-6

Hello Ladies,

I am normally a lurker but with all this talk about Lecithin,
Inositol and such I had to throw in my two cents. I have been doing
research on sources for d-chiro inositol for a while and looking for
ways to get more of it in my body. One of the searches I did yielded
some info about how Pinitol is converted to d-chiro inositol in the
body. I found that Pinitol was being imported from New Zealand and
included in some supplements in the US. One of these was called d-
Pinitol and was being sold under the GNC label. I immediately went
out and got some for myself and my sister who also has PCOS and Type
II Diabetes as well. I have PCOS but not diabetic yet. I starting
taking it a couple times a day to start and noticed within a couple
of weeks that I was having quite a bit of "twingeing" in the ovary
area. Right after this I started having some severe back pain and
was afraid that it was being caused by the Pinitol so I discontinued
it. It turned out to be a herniated disk so I don't think it had
anything to do with the Pinitol.

I just this week have started taking Soy Lecithin, along with the
Pinitol, and IP-6 which is (Inositol Hexaphosphate) and within a
couple of days of starting these I am having the "twingeing" again.
I have also lost about 25 pounds in the last few months by mostly
changing diet and exercise. I am feeling a lot better and am hoping
that these sources of inositol are really giving my body what it
needs at last. I am 34 and will be 35 next month and I would like to
have another child. I have a son who is 15 already and have wanted
to have another child for at least ten years but really didn't want
to go the fertility drug route. This list is very encouraging. I
will keep you posted on my progress.

posted 05-02-2002 04:53 PM       

Here are items that contain d-chiro inositol and some sources to get them:

buckwheat products
I got buckwheat farinetta from http://www.minndak.com/buckwhea.htm. They were a bit of a struggle for me to deal with.

soybean
mung bean

Here are some items that contain pinitol:

soybean
pigeon pea
lentil
chickpea
adzuki beans
carob http://www.cgaweb.com/ingles/index_5.htm These people didn't want to deal with me directly so I have purchased my carob syrup from John Kenney at sjkenney@inreach.com.

posted 05-14-2002 10:42 AM       

Also fixed the link to the buckwheat people above.